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Cardiac Physiology

Season 2

  • LDL receptor


    A Venus fly-trap mechanism of LDL uptake; the special status of Familial Hypercholesterolaemia.

  • Re-Entry


    Cardiac currents do donuts too! An introduction to laddergrams. From season 2.

  • Pleiotropic effects


    Statins and the HMGCoA reductase pathway, beyond cholesterol. Maybe you missed chemistry at high school. From season 2.

  • Antiplatelet drugs


    The cycloxygenase pathway, the receptor for ADP, fibrinogen binding to the IIb,IIIa receptor. Where does your drug act? From season 2.

  • Diastole


    Diastole takes energy. The importance of ischaemia. Dysfunction is like a stiff back.

  • Lipoprotein (a)


    Maybe the link between lipoproteins and thrombosis, Lp(a) is one of the strongest genetic loci for coronary disease. What is a kringle?

  • Mitral apparatus


    More about the mitral valve. The chords and papillary muscles assist left ventricular systole.

Season 1

  • Normal coronary flow


    How the coronary circulation increases flow to regional beds. The nitric (not nitrous) oxide story.

  • Supply / Demand


    Living on a coronary blood flow budget. The pressure-volume loop.

  • Preload, afterload & contractility


    How the left ventricle performs in systole, or how the donkey gets it's load up the hill.

  • Coronary Perfusion Pressure**

    The heart is like a sponge; coronary perfusion pressure falls when LV diastolic pressure rises.

  • Left ventricular hypertrophy


    How both concentric and eccentric LVH develop to normalise wall stress

  • Ejection Fraction & Endsystolic Volume


    More about the LV in systole, EF is an old measure to correct for errors in estimating absolute LV volume. It can be misleading.

  • Key:
  • Basic
  • Detailed
  • Advanced
  • Controversial